Yesterday I finished Oryx and Crake by Margaret Atwood.

A fairly standard post-apocalyptic novel, told partly in flashback as the protagonist, one of the only surviving normal humans, remembers his youth and interactions with the person responsible for the fall of humanity and partly in the present, as the protagonist struggles to survive, and look after  a group of altered, genetic engineered humans.

The only non-standard thing about this novel is the fact that Margaret Atwood doesn't consider it science fiction.  That just reveals that she isn't exposed to much in the field, since her novel fits neatly within the genre in every way.